Here is, I. The apprehension David was in of danger from his enemies. 1. They were very malicious, and industrious in prosecuting their malicious designs: They follow after mischief, any mischief they could do to David or his friends; they would let slip no opportunity nor let fall any pursuit that might be to his hurt. 2. They were very impious, and had no fear of God before their eyes: They are far from thy law, setting themselves as far as they can out of the reach of its convictions and commands. The persecutors of God's people are such as make light of God himself; we may therefore be sure that God will take his people's part against them. 3. They followed him closely and he was just ready to fall into their hands: They draw nigh, nigher than they were; so that they got ground of him. They were at his heels, just upon his back. God sometimes suffers persecutors to prevail very far against his people, so that, as David said (Sa1 20:3), There is but a step between them and death. Perhaps this comes in here as a reason why David was so earnest in prayer, Psa 119:149. God brings us into imminent perils, as he did Jacob, that, like him, we may wrestle for a blessing.
II. The assurance David had of protection with God: "They draw nigh to destroy me, but thou art near, O Lord! to save me, not only mightier than they and therefore able to help me against them, but nearer than they and therefore ready to help." It is the happiness of the saints that, when trouble is near, God is near, and no trouble can separate between them and him. He is never far to seek, but he is within our call, and means are within his call, Deu 4:7. All thy commandments are truth. The enemies thought to defeat the promises God had made to David, but he was sure it was out of their power; they were inviolably true, and would be infallibly performed.

Plead my cause, and deliver me,.... This shows that his affliction was chiefly from men, wicked, ungodly, and unreasonable men; such as were Saul and his courtiers, and a whole ungodly nation: his cause was a good one, and therefore he puts it into the hand of the Lord, and who otherwise would not have undertaken it; and this he did also because he could not plead it himself, nor any other for him but the Lord; his enemies that strove with him being so many, mighty, and crafty; see Psa 35:1. Christ is the advocate of his people, their Redeemer, who is mighty, and thoroughly pleads their cause against the accusations of Satan, the charges of law and justice, and the condemnation of their own hearts; as well as defends their innocence from the calumnies of wicked men, and rights their wrongs, and redresses their grievances;

quicken me according to thy word; See Gill on Psa 119:25.